Obese individuals who
lose as little as 5 percent of their body weight can improve their
metabolic function and reduce the risk of developing Type 2 diabetes and
heart disease, a new study has found.
Many current treatment
guidelines urge patients to lose between 5 percent and 10 percent of
their body weight in order to experience health benefits, but the
recommendations were based on earlier studies that didn’t distinguish
between participants who lost only 5 percent of their weight and those
who lost more.
The study, a clinical
trial, randomized 40 obese individuals with signs of insulin resistance
to either maintain their body weight or go on a low-calorie diet and
lose 5 percent, 10 percent or 15 percent of their body weight.
It found that insulin
sensitivity improved significantly after participants lost just 5
percent of their body weight, as did triglyceride concentrations, blood
pressure and heart rate. There were no improvements in markers of
inflammation at that level of weight loss, however.
“Losing 5 percent is
much easier than losing 10 percent, so it was important to understand
what the differences might be,” said Dr. Samuel Klein, a professor at
Washington University School of Medicine and senior author of the study,
published in the journal Cell Metabolism. “You get a big bang for your buck with 5 percent.”
Obese individuals who
lose as little as 5 percent of their body weight can improve their
metabolic function and reduce the risk of developing Type 2 diabetes and
heart disease, a new study has found.
Many current treatment
guidelines urge patients to lose between 5 percent and 10 percent of
their body weight in order to experience health benefits, but the
recommendations were based on earlier studies that didn’t distinguish
between participants who lost only 5 percent of their weight and those
who lost more.
The study, a clinical
trial, randomized 40 obese individuals with signs of insulin resistance
to either maintain their body weight or go on a low-calorie diet and
lose 5 percent, 10 percent or 15 percent of their body weight.
It found that insulin
sensitivity improved significantly after participants lost just 5
percent of their body weight, as did triglyceride concentrations, blood
pressure and heart rate. There were no improvements in markers of
inflammation at that level of weight loss, however.
“Losing 5 percent is
much easier than losing 10 percent, so it was important to understand
what the differences might be,” said Dr. Samuel Klein, a professor at
Washington University School of Medicine and senior author of the study,
published in the journal Cell Metabolism. “You get a big bang for your buck with 5 percent.”



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